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Protection of inactivated vaccine against SARS-CoV-2 infections in patients with comorbidities: a prospective

Frontiers of Medicine   Pages 867-877 doi: 10.1007/s11684-023-0995-9

Abstract: Protection against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection of inactivated vaccines is not well characterized in people with comorbidities, who are at high risk of severe infection. We compared the risk of SARS-CoV-2 infection after complete vaccination with Sinopharm/BBIBP in people with comorbidities (e.g., autoimmune diseases, cardiovascular disease, chronic lung disease, and diabetes) with healthy individuals using a Cox-proportional hazard model. In July–September 2021, a total of 10 548 people (comorbidities, 2143; healthy, 8405) receiving the complete primary series of vaccination with Sinopharm/BBIBP in Bangkok, Thailand were prospectively followed for SARS-CoV-2 infection through text messaging and telephone interviewing for 6 months. A total of 295 infections from 284 participants were found. HRs (95% CI) of individuals with any comorbidities did not increase (unadjusted, 1.02 (0.77–1.36), P = 0.89; adjusted, 1.04 (0.78–1.38), P = 0.81). HRs significantly increased in the subgroup of autoimmune diseases (unadjusted, 2.64 (1.09–6.38), P = 0.032; adjusted, 4.45 (1.83–10.83), P = 0.001) but not in cardiovascular disease, chronic lung disease, or diabetes. The protection against SARS-CoV-2 infection of the Sinopharm vaccine was similar in participants with any comorbidities vs. healthy individuals. However, the protection appeared lower in the subgroup of autoimmune diseases, which may reflect suboptimal immune responses among these people.

Keywords： COVID-19     Sinopharm/BBIBP vaccine     immunocompromised patients     real-world    

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A comprehensive information database (CID) of breast cancer patients in China

Shuai Li, Li Fu

Frontiers of Medicine 2012, Volume 6, Issue 2,   Pages 212-216 doi: 10.1007/s11684-012-0185-7

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Reliability of foam posturography in assessment of postural balance in the patients with vertigo

LIU Bo, KONG Weijia

Frontiers of Medicine 2008, Volume 2, Issue 4,   Pages 361-365 doi: 10.1007/s11684-008-0069-z

Abstract: To our knowledge, there is no report about the test-retest reliability of foam posturography in the patientsThe foam posturography was taken on the patients with vertigo in stable state and repeated in 3 to 5The results of patients with vertigo were compared with those of normal subjects.There were 10 of 34 patients with vertigo at least fell one time during the two assessments, and the(1) The interclass correlation coefficients (ICC) of all 49 subjects including normal subjects and patients
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Efficacy and safety of JAK inhibitor INC424 in patients with primary and post-polycythemia vera or post-essential

Xin Du,Daobin Zhou

Frontiers of Medicine 2016, Volume 10, Issue 4,   Pages 437-443 doi: 10.1007/s11684-016-0472-9

Abstract: A2202) was performed to evaluate the efficacy and safety of JAK inhibitor ruxolitinib in 63 Chinese MF patientsAbout 94.7% of the patients achieved a reduction in spleen size, 27.0% of which exhibited significantSignificant improvement in debilitating constitutional symptoms, as assessed by MFSAF v2.0, was observed in patientsRuxolitinib treatment was generally well tolerated by Chinese patients.substantial reductions in splenomegaly and improvements in symptoms, and was well-tolerated by Chinese patients

Keywords： JAK     ruxolitinib     Chinese patients     myelofibrosis    

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Translating the power of TCM into patients’ hope

Guangbiao Zhou,Zhu Chen

Frontiers of Medicine 2014, Volume 8, Issue 3,   Pages 265-267 doi: 10.1007/s11684-014-0329-z

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Hypertension in patients with CKD in China: clinical characteristics and management

Guangyan Cai, Xiangmei Chen

Frontiers of Medicine 2017, Volume 11, Issue 3,   Pages 307-309 doi: 10.1007/s11684-017-0578-8

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Predictive values of plasma TNFα and IL-8 for intracranial hemorrhage in patients with acute promyelocytic

Frontiers of Medicine 2022, Volume 16, Issue 6,   Pages 909-918 doi: 10.1007/s11684-021-0890-1

Abstract: In patients with acute promyelocytic leukemia (APL), intracranial hemorrhage (ICH), if not identifiedHere, cytokine differences between patients with APL with and without ICH were investigated to developof cytokines that were remarkedly different between patients with APL and healthy controls.The APL patients were subsequently divided into high and low white blood cell count groups.In addition, verification in 81 patients with APL demonstrated that the two cytokines were positively

Keywords： acute promyelocytic leukemia     intracranial hemorrhage     cytokines     biomarker    

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Effects of combined procedure and devascularization alone on hyperdynamics of the portal venous system in patients

HUA Rong, SUN Yongwei, WU Zhiyong

Frontiers of Medicine 2008, Volume 2, Issue 3,   Pages 244-247 doi: 10.1007/s11684-008-0046-6

Abstract: In 20 patients who received CP and 18 who received PCDV, hemodynamic parameters of the portal venousthe normal anatomic structure of hepatic portal system, thus it should be one of the best choices for patients
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The clinical impact of tricuspid regurgitation in patients with a biatrial orthotopic heart transplant

Frontiers of Medicine 2023, Volume 17, Issue 3,   Pages 527-533 doi: 10.1007/s11684-022-0967-5

Abstract: All consecutive adult patients undergoing biatrial OHT (1984−2017) with an available follow-up echocardiogramIn total, 572 patients were included (median age: 50 years, males: 74.9%).Approximately 32% of patients had moderate-to-severe TR immediately after surgery.

Keywords： orthotopic heart transplant     tricuspid regurgitation     clinical impact     biatrial heart transplantation    

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Hybrid deep learning model for risk prediction of fracture in patients with diabetes and osteoporosis

Frontiers of Medicine 2022, Volume 16, Issue 3,   Pages 496-506 doi: 10.1007/s11684-021-0828-7

Abstract: The fracture risk of patients with diabetes is higher than those of patients without diabetes due tosuch as bone mineral density, blood routine, and urine routine) may be related to bone metabolism in patientsIn addition, the fracture risk of patients with diabetes and osteoporosis has not been further studiedwith diabetes and osteoporosis, and investigate the effect of patients’ physiological factors on fractureMoreover, the top 18 influencing factors of fracture risks of patients with diabetes are determined.

Keywords： XGBoost     deep neural network     healthcare     risk prediction    

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The early percutaneous coronary intervention in elderly patients with acute coronary syndrome

HUANG Xiong, CAO Xuebin, ZHANG Gang

Frontiers of Medicine 2008, Volume 2, Issue 1,   Pages 15-18 doi: 10.1007/s11684-008-0004-3

Abstract: Fifteen patients older than 65 years with ACS within 24 hours of the event were admitted from April 4All the patients had early percutaneous coronary intervention and were followed up for 6–12 months byNine of the 15 patients exhibited acute myocardial infarction (AMI).All the patients had early PCI. The average door-to-balloon time was 78 minutes (40–110 minutes).Nineteen of 36 lesions in the fifteen angioplasty patients were treated and 20 stents were implanted

Keywords： door-to-balloon     percutaneous intervention     coronary syndrome     angioplasty     successful    

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Beneficial effects of preventive cholecystectomy in patients with hepatic cancer

LIU Anzhong, LI Jun, HUA Huwei

Frontiers of Medicine 2008, Volume 2, Issue 2,   Pages 139-142 doi: 10.1007/s11684-008-0026-x

Abstract: The survival rate of patients with hepatic cancer for more than two years has been increased, and theincidence of complications of cholecystitis and gall stone are relatively higher among these patientsinvestigation from 2002 to 2006 to assess the clinical significance of preventive cholecystectomy in patientsOne hundred and eighteen cases of postoperative patients with hepatic cancer, who survived for more thanBased on whether cholecystectomy was performed, the patients were divided into two groups including 48
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Identification of surgical patients at high risk of OSAS using the Berlin Questionnaire to detect potential

Fei Liu, Li Liu, Fang Zheng, Xiangdong Tang, Yongxin Bao, Yunxia Zuo

Frontiers of Medicine 2018, Volume 12, Issue 2,   Pages 189-195 doi: 10.1007/s11684-017-0533-8

Abstract: This study uses Berlin Questionnaire (BQ) to identify Chinese adult surgical patients who are at a highResults indicated that only 11.4% of the patients were considered at a high risk of OSAS.Furthermore, the incidence of adverse respiratory events in the PACU was higher in patients with highThe BQ may be adopted as a screening tool for anesthesiologists in China to identify patients who are

Keywords： obstructive sleep apnea     Berlin Questionnaire     Chinese surgical patients     adverse respiratory event    

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Effectiveness of quality of care for patients with type 2 diabetes in China: findings from the Shanghai

Frontiers of Medicine 2022, Volume 16, Issue 1,   Pages 126-138 doi: 10.1007/s11684-021-0897-7

Abstract: A total of 173 235 patients with type 2 diabetes in 2017 were included in the analysis.The patients had a mean age of 66.43±8.12 (standard deviation (SD)) years and a mean diabetes durationThe percentage of patients who achieved the target level for HbA1c (<7.0%) was 48.6%.In conclusion, nearly 50% and one-third of the patients with diabetes met the target levels for HbApatients who achieved all three target levels needs significant improvement.

Keywords： type 2 diabetes     quality of care     macrovascular complication     microvascular complication     treatment pattern     epidemiology    

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Strategies for preventing peritoneal fibrosis in peritoneal dialysis patients: new insights based on

Zhen Zhang, Na Jiang, Zhaohui Ni

Frontiers of Medicine 2017, Volume 11, Issue 3,   Pages 349-358 doi: 10.1007/s11684-017-0571-2

Abstract:

Peritoneal dialysis (PD) is an established form of renal replacement therapy. Long-term PD leads to morphologic and functional changes to the peritoneal membrane (PM), which is defined as peritoneal fibrosis, a known cause of loss of peritoneal ultrafiltration capacity. Inflammation and angiogenesis are key events during the pathogenesis of peritoneal fibrosis. This review discusses the pathophysiology of peritoneal fibrosis and recent research progress on key fibrogenic molecular mechanisms in peritoneal inflammation and angiogenesis, including Toll-like receptor ligand-mediated, NOD-like receptor protein 3/interleukin-1β, vascular endothelial growth factor, and angiopoietin-2/Tie2 signaling pathways. Furthermore, novel strategies targeting peritoneal inflammation and angiogenesis to preserve the PM are discussed in depth.

Keywords： peritoneal dialysis     peritoneal fibrosis     inflammation     angiogenesis    

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Title Author Date Type Operation

Protection of inactivated vaccine against SARS-CoV-2 infections in patients with comorbidities: a prospective

Journal Article

A comprehensive information database (CID) of breast cancer patients in China

Shuai Li, Li Fu

Journal Article

Reliability of foam posturography in assessment of postural balance in the patients with vertigo

LIU Bo, KONG Weijia

Journal Article

Efficacy and safety of JAK inhibitor INC424 in patients with primary and post-polycythemia vera or post-essential

Xin Du,Daobin Zhou

Journal Article

Translating the power of TCM into patients’ hope

Guangbiao Zhou,Zhu Chen

Journal Article

Hypertension in patients with CKD in China: clinical characteristics and management

Guangyan Cai, Xiangmei Chen

Journal Article

Predictive values of plasma TNFα and IL-8 for intracranial hemorrhage in patients with acute promyelocytic

Journal Article

Effects of combined procedure and devascularization alone on hyperdynamics of the portal venous system in patients

HUA Rong, SUN Yongwei, WU Zhiyong

Journal Article

The clinical impact of tricuspid regurgitation in patients with a biatrial orthotopic heart transplant

Journal Article

Hybrid deep learning model for risk prediction of fracture in patients with diabetes and osteoporosis

Journal Article

The early percutaneous coronary intervention in elderly patients with acute coronary syndrome

HUANG Xiong, CAO Xuebin, ZHANG Gang

Journal Article

Beneficial effects of preventive cholecystectomy in patients with hepatic cancer

LIU Anzhong, LI Jun, HUA Huwei

Journal Article

Identification of surgical patients at high risk of OSAS using the Berlin Questionnaire to detect potential

Fei Liu, Li Liu, Fang Zheng, Xiangdong Tang, Yongxin Bao, Yunxia Zuo

Journal Article

Effectiveness of quality of care for patients with type 2 diabetes in China: findings from the Shanghai

Journal Article

Strategies for preventing peritoneal fibrosis in peritoneal dialysis patients: new insights based on

Zhen Zhang, Na Jiang, Zhaohui Ni

Journal Article